Molecular hydrogen reduces oxidative stress in rheumatoid arthritis
February 8, 2017
Metabolic Syndrome and Hydrogen Rich Water
Metabolic syndrome is characterized by cardio-metabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia.
Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome.
The objective of this study was to examine the effectiveness of hydrogen rich water (1.5–2 L/day), 8-week study on 20 subjects with potential metabolic syndrome.
Hydrogen rich water was produced, by placing a Alkaline stick into drinking water, by the following chemical reaction:
Mg + 2H2O → Mg (OH)2 + H2.
Oxidative stress is a well-recognized mechanism playing an important role in pathological conditions seen in metabolic syndrome.
TBARS are a marker of lipid peroxidation which is indicative of malondialdehyde formation and lipid damage and is a well-established method for screening and monitoring lipid peroxidation.
The concentration of urinary TBARS decreased significantly (p<0.05) from baseline to week 4 and week 8. Subjects demonstrated a significant increase (p<0.05) in SOD from baseline to week 8.
Subjects demonstrated increasing trends in 8-isoprostane from baseline to week 4 and week 8. When a post hoc sub analysis by gender was conducted, male subjects demonstrated a significant decrease in urinary TBARS from baseline to week 8 and a significant increase (p<0.05) in SOD from baseline to week 8.
During oxidative damage to DNA, damaged products are usually eliminated by repair enzymes and detected as nucleoside derivatives.
Urinary 8-OHdG is one adduct of this reaction and has been proposed as a sensitive biomarker of oxidative DNA damage and repair .
In subjects who were current smokers, there was a trend toward a decrease in urinary 8-OHdG and TBARS levels from baseline to week 4 and week 8.
Subjects demonstrated increasing trends in SOD from baseline to week 8 and 8-isoprostane from baseline to week 4 and week 8. Urinary 8-OHdG, 8-isoprostane, TBARS and SOD were higher in subjects who were current smokers .
results
The consumption of hydrogen rich water for 8 weeks resulted in a 39% increase in antioxidant enzyme superoxide dismutase (SOD).
Further, subjects demonstrated an 8% increase in high density lipoprotein (HDL)-cholesterol and a 13% decrease in total cholesterol/HDL-cholesterol from baseline to week 4.
In conclusion, drinking hydrogen rich water represents a potentially novel therapeutic and preventive strategy for metabolic syndrome.
The portable alkaline stick was a safe, easy and effective method of delivering hydrogen rich water for daily consumption byarticipants in the study.
